Acute bioenergetic insulin sensitivity of skeletal muscle cells: ATP-demand-provoked glycolysis contributes to stimulation of ATP supply

Skeletal muscle takes up glucose in an insulin-sensitive manner and is thus important for the maintenance of blood glucose homeostasis. Insulin resistance during development of type 2 diabetes is associated with decreased ATP synthesis, but the causality of this association is controversial. In this...

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Autors principals: Rosie A. Donnell, Jane E. Carré, Charles Affourtit
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2022-07-01
Col·lecció:Biochemistry and Biophysics Reports
Matèries:
Skeletal muscle insulin resistance
Cellular energy metabolism
Efficiency of mitochondrial ATP synthesis
ATP demand
Oxidative phosphorylation
Type 2 diabetes
Accés en línia:http://www.sciencedirect.com/science/article/pii/S2405580822000747
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