Mammalian Emi2 mediates cytostatic arrest and transduces the signal for meiotic exit via Cdc20

Fertilizable mammalian oocytes are arrested at the second meiotic metaphase (mII) by the cyclinB-Cdc2 heterodimer, maturation promoting factor (MPF). MPF is stabilized via the activity of an unidentified cytostatic factor (CSF), thereby suspending meiotic progression until fertilization. We here pre...

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Bibliographic Details
Main Authors: Shoji, Shisako, Yoshida, Naoko, Amanai, Manami, Ohgishi, Maki, Fukui, Tomoyuki, Fujimoto, Satoko, Nakano, Yoshikazu, Kajikawa, Eriko, Perry, Anthony C F
Format: Artigo
Language:Inglês
Published: 2006
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1383546/
https://ncbi.nlm.nih.gov/pubmed/16456547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600953
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