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The role of seladin-1/DHCR24 in cholesterol biosynthesis, APP processing and Aβ generation in vivo
The cholesterol-synthesizing enzyme seladin-1, encoded by the Dhcr24 gene, is a flavin adenine dinucleotide-dependent oxidoreductase and regulates responses to oncogenic and oxidative stimuli. It has a role in neuroprotection and is downregulated in affected neurons in Alzheimer's disease (AD)....
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| Main Authors: | , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2006
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1383521/ https://ncbi.nlm.nih.gov/pubmed/16407971 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600938 |
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