Human antibodies for immunotherapy development generated via a human B cell hybridoma technology

Current strategies for the production of therapeutic mAbs include the use of mammalian cell systems to recombinantly produce Abs derived from mice bearing human Ig transgenes, humanization of rodent Abs, or phage libraries. Generation of hybridomas secreting human mAbs has been previously reported;...

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Autori principali: Li, Jian, Sai, Tao, Berger, Marc, Chao, Qimin, Davidson, Diane, Deshmukh, Gaurav, Drozdowski, Brian, Ebel, Wolfgang, Harley, Stephen, Henry, Marianne, Jacob, Sara, Kline, Brad, Lazo, Ella, Rotella, Frank, Routhier, Eric, Rudolph, Kathryn, Sage, Jeaneen, Simon, Paul, Yao, Jun, Zhou, Yuhong, Kavuru, Mani, Bonfield, Tracey, Thomassen, Mary Jane, Sass, Philip M., Nicolaides, Nicholas C., Grasso, Luigi
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2006
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1383494/
https://ncbi.nlm.nih.gov/pubmed/16505368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0511285103
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