Human antibodies for immunotherapy development generated via a human B cell hybridoma technology

Current strategies for the production of therapeutic mAbs include the use of mammalian cell systems to recombinantly produce Abs derived from mice bearing human Ig transgenes, humanization of rodent Abs, or phage libraries. Generation of hybridomas secreting human mAbs has been previously reported;...

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Autors principals: Li, Jian, Sai, Tao, Berger, Marc, Chao, Qimin, Davidson, Diane, Deshmukh, Gaurav, Drozdowski, Brian, Ebel, Wolfgang, Harley, Stephen, Henry, Marianne, Jacob, Sara, Kline, Brad, Lazo, Ella, Rotella, Frank, Routhier, Eric, Rudolph, Kathryn, Sage, Jeaneen, Simon, Paul, Yao, Jun, Zhou, Yuhong, Kavuru, Mani, Bonfield, Tracey, Thomassen, Mary Jane, Sass, Philip M., Nicolaides, Nicholas C., Grasso, Luigi
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2006
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1383494/
https://ncbi.nlm.nih.gov/pubmed/16505368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0511285103
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