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Ubiquitin-dependent lysosomal degradation of the HNE-modified proteins in lens epithelial cells
4-Hydroxynonenal (HNE), a highly reactive lipid peroxidation product, may adversely modify proteins. Accumulation of HNE-modified proteins may be responsible for pathological lesions associated with oxidative stress. The objective of this work was to determine how HNE-modified proteins are removed f...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1382276/ https://ncbi.nlm.nih.gov/pubmed/15247152 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.04-1743fje |
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