Ubiquitin-dependent lysosomal degradation of the HNE-modified proteins in lens epithelial cells

4-Hydroxynonenal (HNE), a highly reactive lipid peroxidation product, may adversely modify proteins. Accumulation of HNE-modified proteins may be responsible for pathological lesions associated with oxidative stress. The objective of this work was to determine how HNE-modified proteins are removed f...

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Bibliographic Details
Main Authors: Marques, Carla, Pereira, Paulo, Taylor, Allen, Liang, Jack N., Reddy, Venkat N., Szweda, Luke I., Shang, Fu
Format: Artigo
Language:Inglês
Published: 2004
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1382276/
https://ncbi.nlm.nih.gov/pubmed/15247152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.04-1743fje
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