Impaired inflammatory pain and thermal hyperalgesia in mice expressing neuron-specific dominant negative mitogen activated protein kinase kinase (MEK)

BACKGROUND: Numerous studies have implicated spinal extracellular signal-regulated kinases (ERKs) as mediators of nociceptive plasticity. These studies have utilized pharmacological inhibition of MEK to demonstrate a role for ERK signaling in pain, but this approach cannot distinguish between effect...

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Detalhes bibliográficos
Main Authors: Karim, Farzana, Hu, Hui-Juan, Adwanikar, Hita, Kaplan, David, Gereau, Robert W
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2006
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1382249/
https://ncbi.nlm.nih.gov/pubmed/16412244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-2-2
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