Inhibition of Akt increases p27(Kip1) levels and induces cell cycle arrest in anaplastic large cell lymphoma

Anaplastic large cell lymphoma (ALCL) is a highly proliferative neoplasm that frequently carries the t(2;5)(p23;q35) and aberrantly expresses nucleophosmin–anaplastic lymphoma kinase (NPM-ALK). Previously, NPM-ALK had been shown to activate the phosphatidylinositol 3 kinase (PI3K)/Akt pathway. As th...

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Detalhes bibliográficos
Main Authors: Rassidakis, George Z., Feretzaki, Marianna, Atwell, Coralyn, Grammatikakis, Ioannis, Lin, Quan, Lai, Raymond, Claret, Francois-Xavier, Medeiros, L. Jeffrey, Amin, Hesham M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1382060/
https://ncbi.nlm.nih.gov/pubmed/15374880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2004-06-2125
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