Inducible expression of a degradation-resistant form of p27(Kip1) causes growth arrest and apoptosis in breast cancer cells

The cyclin-dependent kinase (CDK) inhibitor p27(Kip1) (p27) is an important regulator of cell cycle progression controlling the transition from G to S-phase. Low p27 levels or accelerated p27 degradation correlate with excessive cell proliferation and poor prognosis in several forms of cancer. Phosp...

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Hlavní autoři: Zhang, Qingxiu, Tian, Ling, Mansouri, Abdel, Korapati, Anita L., Johnson, Terry J., Claret, Francois X.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2005
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1366489/
https://ncbi.nlm.nih.gov/pubmed/15996662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2005.06.012
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