Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites

Helicobacter pylori is a causative agent of gastritis and peptic ulcer. cagA(+) H. pylori strains are more virulent than cagA(−) strains and are associated with gastric carcinoma. The cagA gene product, CagA, is injected by the bacterium into gastric epithelial cells and subsequently undergoes tyros...

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Main Authors: Higashi, Hideaki, Tsutsumi, Ryouhei, Fujita, Akiko, Yamazaki, Shiho, Asaka, Masahiro, Azuma, Takeshi, Hatakeyama, Masanori
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2002
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC137900/
https://ncbi.nlm.nih.gov/pubmed/12391297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.222375399
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