Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites

Helicobacter pylori is a causative agent of gastritis and peptic ulcer. cagA(+) H. pylori strains are more virulent than cagA(−) strains and are associated with gastric carcinoma. The cagA gene product, CagA, is injected by the bacterium into gastric epithelial cells and subsequently undergoes tyros...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Higashi, Hideaki, Tsutsumi, Ryouhei, Fujita, Akiko, Yamazaki, Shiho, Asaka, Masahiro, Azuma, Takeshi, Hatakeyama, Masanori
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2002
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC137900/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12391297/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.222375399
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