Uptake of the anticancer drug cisplatin mediated by the copper transporter Ctr1 in yeast and mammals

Cisplatin is a chemotherapeutic drug used to treat a variety of cancers. Both intrinsic and acquired resistance to cisplatin, as well as toxicity, limit its effectiveness. Molecular mechanisms that underlie cisplatin resistance are poorly understood. Here we demonstrate that deletion of the yeast CT...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Ishida, Seiko, Lee, Jaekwon, Thiele, Dennis J., Herskowitz, Ira
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2002
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC137878/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12370430/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.162491399
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