Structure of the GCN5 histone acetyltransferase bound to a bisubstrate inhibitor

Histone acetyltransferases (HATs) use acetyl CoA to acetylate target lysine residues within histones and other transcription factors, such as the p53 tumor suppressor, to promote gene activation. HAT enzymes fall into subfamilies with divergence in sequence and substrate preference. Several HAT prot...

Полное описание

Библиографические подробности

Опубликовано в::	Proc Natl Acad Sci U S A
Главные авторы:	Poux, Arienne N., Cebrat, Marek, Kim, Cheol M., Cole, Philip A., Marmorstein, Ronen
Формат:	Artigo
Язык:	Inglês
Опубликовано:	National Academy of Sciences 2002
Предметы:	Biological Sciences
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC137837/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12391296/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.222373899
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