Structure of the GCN5 histone acetyltransferase bound to a bisubstrate inhibitor

Histone acetyltransferases (HATs) use acetyl CoA to acetylate target lysine residues within histones and other transcription factors, such as the p53 tumor suppressor, to promote gene activation. HAT enzymes fall into subfamilies with divergence in sequence and substrate preference. Several HAT prot...

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Dades bibliogràfiques

Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Poux, Arienne N., Cebrat, Marek, Kim, Cheol M., Cole, Philip A., Marmorstein, Ronen
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 2002
Matèries:	Biological Sciences
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC137837/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12391296/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.222373899
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