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Neighboring-nucleotide effects on the rates of germ-line single-base-pair substitution in human genes.

The spectrum of single-base-pair substitutions logged in The Human Gene Mutation Database (HGMD), comprising 7,271 different lesions in the coding regions of 547 different human genes, was analyzed for nearest-neighbor effects on relative mutation rates. Owing to its retrospective nature, HGMD allow...

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Main Authors: Krawczak, M, Ball, E V, Cooper, D N
Formato: Artigo
Idioma:Inglês
Publicado: 1998
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1377306/
https://ncbi.nlm.nih.gov/pubmed/9683596
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