Production of maternal-zygotic mutant zebrafish by germ-line replacement

We report a generally applicable strategy for transferring zygotic lethal mutations through the zebrafish germ line. By using a morpholino oligonucleotide that blocks primordial germ cell (PGC) development, we generate embryos devoid of endogenous PGCs to serve as hosts for the transplantation of ge...

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Bibliographic Details
Main Authors: Ciruna, Brian, Weidinger, Gilbert, Knaut, Holger, Thisse, Bernard, Thisse, Christine, Raz, Erez, Schier, Alexander F.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2002
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC137520/
https://ncbi.nlm.nih.gov/pubmed/12397179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.222459999
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