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Distinct domains in the CArG-box binding factor A destabilize tetraplex forms of the fragile X expanded sequence d(CGG)(n)

Formation of hairpin or tetraplex structures of the FMR1 gene d(CGG)(n) sequence triggers its expansion, setting off fragile X syndrome. In searching for proteins that destabilize d(CGG)(n) secondary structures we purified from rat liver quadruplex telomeric DNA binding protein 42 (qTBP42) that disr...

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Main Authors: Weisman-Shomer, Pnina, Cohen, Esther, Fry, Michael
格式: Artigo
語言:Inglês
出版: Oxford University Press 2002
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC137428/
https://ncbi.nlm.nih.gov/pubmed/12202751
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