Polyamine structural effects on the induction and stabilization of liquid crystalline DNA: potential applications to DNA packaging, gene therapy and polyamine therapeutics

DNA undergoes condensation, conformational transitions, aggregation and resolubilization in the presence of polyamines, positively charged organic molecules present in all cells. Under carefully controlled environmental conditions, DNA can also transform to a liquid crystalline state in vitro. We un...

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Bibliographic Details

Published in:	Nucleic Acids Res
Main Authors:	Saminathan, M., Thomas, Thresia, Shirahata, Akira, Pillai, C. K. S., Thomas, T. J.
Format:	Artigo
Language:	Inglês
Published:	Oxford University Press 2002
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC137425/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12202757/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkf503
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