Polyamine structural effects on the induction and stabilization of liquid crystalline DNA: potential applications to DNA packaging, gene therapy and polyamine therapeutics

DNA undergoes condensation, conformational transitions, aggregation and resolubilization in the presence of polyamines, positively charged organic molecules present in all cells. Under carefully controlled environmental conditions, DNA can also transform to a liquid crystalline state in vitro. We un...

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Veröffentlicht in:	Nucleic Acids Res
Hauptverfasser:	Saminathan, M., Thomas, Thresia, Shirahata, Akira, Pillai, C. K. S., Thomas, T. J.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Oxford University Press 2002
Schlagworte:	Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC137425/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12202757/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkf503
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