Radiation Therapy Potentiates Effective Oncolytic Viral Therapy in the Treatment of Lung Cancer

BACKGROUND: Replication-competent oncolytic herpes simplex viruses (HSV) with deletion of the γ(1)34.5 gene preferentially replicate in and kill malignant cells. γ(1)34.5 codes for ICP 34.5, a protein that enhances viral replication, and is homologous to Growth Arrest and DNA damage Protein 34 (GADD...

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Autores principales: Adusumilli, Prasad S., Stiles, Brendon M., Chan, Mei-Ki, Chou, Ting-Chao, Wong, Richard J., Rusch, Valerie W., Fong, Yuman
Formato: Artigo
Lenguaje:Inglês
Publicado: 2005
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1373787/
https://ncbi.nlm.nih.gov/pubmed/16039175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.athoracsur.2005.01.048
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