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Cisplatin-Induced GADD34 Upregulation Potentiates Oncolytic Viral Therapy in the Treatment of Malignant Pleural Mesothelioma
Background: NV1066, a replication-competent oncolytic herpes simplex virus type 1 (HSV-1) attenuated by a deletion in the gene γ(1)34.5, preferentially replicates in and kills malignant cells. γ(1)34.5 encodes ICP34.5, a viral protein essential for productive replication, which has homology with mam...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1383726/ https://ncbi.nlm.nih.gov/pubmed/16294031 |
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