Cisplatin-Induced GADD34 Upregulation Potentiates Oncolytic Viral Therapy in the Treatment of Malignant Pleural Mesothelioma

Background: NV1066, a replication-competent oncolytic herpes simplex virus type 1 (HSV-1) attenuated by a deletion in the gene γ(1)34.5, preferentially replicates in and kills malignant cells. γ(1)34.5 encodes ICP34.5, a viral protein essential for productive replication, which has homology with mam...

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Autori principali: Adusumilli, Prasad S., Chan, Mei-Ki, Chun, Yun Shin, Hezel, Michael, Chou, Ting-Chao, Rusch, Valerie W., Fong, Yuman
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2006
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1383726/
https://ncbi.nlm.nih.gov/pubmed/16294031
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