A carregar...
MDM2–HDAC1-mediated deacetylation of p53 is required for its degradation
The tumor suppressor p53 is stabilized and activated in response to cellular stress through post-translational modifications including acetylation. p300/CBP-mediated acetylation of p53 is negatively regulated by MDM2. Here we show that MDM2 can promote p53 deacetylation by recruiting a complex conta...
Na minha lista:
| Main Authors: | , , , , , , |
|---|---|
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2002
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC137207/ https://ncbi.nlm.nih.gov/pubmed/12426395 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf616 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|