Reduced aggregation and improved specificity of G-rich oligodeoxyribonucleotides containing pyrazolo[3,4-d]pyrimidine guanine bases

Guanine (G)-rich oligodeoxyribonucleotides (ODNs) can form undesired complexes by self association through non-Watson–Crick interactions. These aggregates can compromise performance of DNA probes and make genetic analysis unpredictable. We found that the 8-aza-7-deazaguanine (PPG), a pyrazolo[3,4-d]...

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Main Authors: Kutyavin, Igor V., Lokhov, Sergey G., Afonina, Irina A., Dempcy, Robert, Gall, Alexander A., Gorn, Vladimir V., Lukhtanov, Eugene, Metcalf, Mark, Mills, Alan, Reed, Michael W., Sanders, Sylvia, Shishkina, Irina, Vermeulen, Nicolaas M. J.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2002
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC137177/
https://ncbi.nlm.nih.gov/pubmed/12433999
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