Role of tumor suppressor p53 domains in selective binding to supercoiled DNA

We showed previously that bacterially expressed full-length human wild-type p53b(1–393) binds selectively to supercoiled (sc)DNA in sc/linear DNA competition experiments, a process we termed supercoil-selective (SCS) binding. Using p53 deletion mutants and pBluescript scDNA (lacking the p53 recognit...

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Bibliografski detalji
Glavni autori: Brázdová, Marie, Paleček, Jan, Cherny, Dmitry I., Billová, Sabina, Fojta, Miroslav, Pečinka, Petr, Vojtěšek, Bořivoj, Jovin, Thomas M., Paleček, Emil
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2002
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Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC137164/
https://ncbi.nlm.nih.gov/pubmed/12434001
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