Role of tumor suppressor p53 domains in selective binding to supercoiled DNA

We showed previously that bacterially expressed full-length human wild-type p53b(1–393) binds selectively to supercoiled (sc)DNA in sc/linear DNA competition experiments, a process we termed supercoil-selective (SCS) binding. Using p53 deletion mutants and pBluescript scDNA (lacking the p53 recognit...

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Publié dans:	Nucleic Acids Res
Auteurs principaux:	Brázdová, Marie, Paleček, Jan, Cherny, Dmitry I., Billová, Sabina, Fojta, Miroslav, Pečinka, Petr, Vojtěšek, Bořivoj, Jovin, Thomas M., Paleček, Emil
Format:	Artigo
Langue:	Inglês
Publié:	Oxford University Press 2002
Sujets:	Articles
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC137164/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12434001/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkf616
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