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Expression of the human DNA glycosylase hSMUG1 in Trypanosoma brucei causes DNA damage and interferes with J biosynthesis

In kinetoplastid flagellates such as Trypanosoma brucei, a small percentage of the thymine residues in the nuclear DNA is replaced by the modified base β-d-glucosyl-hydroxymethyluracil (J), mostly in repetitive sequences like the telomeric GGGTTA repeats. In addition, traces of 5-hydroxymethyluracil...

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Detalhes bibliográficos
Main Authors: Ulbert, Sebastian, Cross, Mike, Boorstein, Robert J., Teebor, George W., Borst, Piet
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2002
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC137116/
https://ncbi.nlm.nih.gov/pubmed/12235375
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