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Bcr is a negative regulator of the Wnt signalling pathway
The Wnt signalling pathway can activate transcription of genes such as c-myc through β-catenin. Here, we describe the protein breakpoint cluster region, Bcr, as a negative regulator of this pathway. Bcr can form a complex with β-catenin and negatively regulate expression of c-Myc. Knockdown of Bcr b...
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| Asıl Yazarlar: | , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2005
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1371031/ https://ncbi.nlm.nih.gov/pubmed/16211085 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400536 |
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