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Relating repair susceptibility of carcinogen-damaged DNA with structural distortion and thermodynamic stability

A key issue in the nucleotide excision repair (NER) of bulky carcinogen–DNA adducts is the ability of the NER machinery to recognize and repair certain adducts while failing to repair others. Unrepaired adducts can survive to cause mutations that initiate the carcinogenic process. Benzo[c]phenanthre...

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Bibliografiska uppgifter
I publikationen:Nucleic Acids Res
Huvudupphov: Wu, Min, Yan, Shixiang, Patel, Dinshaw J., Geacintov, Nicholas E., Broyde, Suse
Materialtyp: Artigo
Språk:Inglês
Utgiven: Oxford University Press 2002
Ämnen:
Länkar:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC137070/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12140327/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkf427
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