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Modified nucleotides at the 5′ end of human U2 snRNA are required for spliceosomal E-complex formation
U2 snRNA, a key player in nuclear pre-mRNA splicing, contains a 5′-terminal m(3)G cap and many internal modifications. The latter were shown in vertebrates to be generally required for U2 function in splicing, but precisely which residues are essential and their role in snRNP and/or spliceosome asse...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Copyright 2004 by RNA Society
2004
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1370681/ https://ncbi.nlm.nih.gov/pubmed/15525712 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.7186504 |
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