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Evolution of aptamers with a new specificity and new secondary structures from an ATP aptamer
Small changes in target specificity can sometimes be achieved, without changing aptamer structure, through mutation of a few bases. Larger changes in target geometry or chemistry may require more radical changes in an aptamer. In the latter case, it is unknown whether structural and functional solut...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Copyright 2003 by RNA Society
2003
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1370500/ https://ncbi.nlm.nih.gov/pubmed/14624002 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.5990203 |
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