Pivotal Role of the Non-hr Origin of DNA Replication in the Genesis of Defective Interfering Baculoviruses

The generation of deletion mutants, including defective interfering viruses, upon serial passage of Spodoptera exigua multicapsid nucleopolyhedrovirus (SeMNPV) in insect cell culture has been studied. Sequences containing the non-homologous region origin of DNA replication (non-hr ori) became hyperm...

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Main Authors: Pijlman, Gorben P., Dortmans, Jos C. F. M., Vermeesch, Angela M. G., Yang, Kai, Martens, Dirk E., Goldbach, Rob W., Vlak, Just M.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2002
Teme:
Replication
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC137048/
https://ncbi.nlm.nih.gov/pubmed/11991989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.11.5605-5611.2002
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