An endonuclease activity similar to Xenopus PMR1 catalyzes the degradation of normal and nonsense-containing human β-globin mRNA in erythroid cells

β-globin mRNA bearing a nonsense codon is degraded in the cytoplasm of erythroid cells by endonuclease cleavage, preferentially at UG dinucleotides. An endonuclease activity in polysomes of MEL cells cleaved β-globin and albumin mRNA in vitro at many of the same sites as PMR1, an mRNA endonuclease p...

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Bibliographic Details
Main Authors: BREMER, KIRSTEN A., STEVENS, AUDREY, SCHOENBERG, DANIEL R.
Format: Artigo
Language:Inglês
Published: Copyright 2003 by RNA Society 2003
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1370479/
https://ncbi.nlm.nih.gov/pubmed/12923263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.5720303
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