A Nucleotide Substitution in the tRNA(Lys) Primer Binding Site Dramatically Increases Replication of Recombinant Simian Immunodeficiency Virus Containing a Human Immunodeficiency Virus Type 1 Reverse Transcriptase

A recombinant simian immunodeficiency virus (SIV) derived from strain 239 (SIVmac239) with reverse transcriptase (RT) sequences from human immunodeficiency virus type 1 (HIV-1) strain HXB2 was severely impaired for replication. Detectable p27(Gag) levels were not observed until day 65 and peak p27(G...

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Bibliographic Details
Main Authors: Soderberg, Kelly, Denekamp, Lynn, Nikiforow, Sarah, Sautter, Karen, Desrosiers, Ronald C., Alexander, Louis
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2002
Subjects:
Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC137045/
https://ncbi.nlm.nih.gov/pubmed/11992009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.11.5803-5806.2002
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