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Dissection of a metal-ion-mediated conformational change in Tetrahymena ribozyme catalysis.

Conformational changes are often required for the biological function of RNA molecules. In the Tetrahymena group I ribozyme reaction, a conformational change has been suggested to occur upon binding of the oligonucleotide substrate (S) or the guanosine nucleophile (G), leading to stronger binding of...

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Bibliografske podrobnosti
Main Authors: Shan, Shu-ou, Herschlag, Daniel
Format: Artigo
Jezik:Inglês
Izdano: 2002
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1370303/
https://ncbi.nlm.nih.gov/pubmed/12166641
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