Selection, design, and characterization of a new potentially therapeutic ribozyme.

An in vitro selection was designed to identify RNA-cleaving ribozymes predisposed for function as a drug. The selection scheme required the catalyst to be trans-acting with phosphodiesterase activity targeting a fragment of the Kras mRNA under simulated physiological conditions. To increase stabiliz...

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Detalhes bibliográficos
Main Authors: Zinnen, Shawn P, Domenico, Kristal, Wilson, Mike, Dickinson, Brent A, Beaudry, Amber, Mokler, Victor, Daniher, Andrew T, Burgin, Alex, Beigelman, Leonid
Formato: Artigo
Idioma:Inglês
Publicado em: 2002
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1370244/
https://ncbi.nlm.nih.gov/pubmed/11911367
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