Protein ligands mediate the CRM1-dependent export of HuR in response to heat shock.

AU-rich elements (AREs) located in the 3' UTRs of the messenger RNAs (mRNAs) of many mammalian early response genes promote rapid mRNA turnover. HuR, an RRM-containing RNA-binding protein, specifically interacts with AREs, stabilizing these mRNAs. HuR is primarily nucleoplasmic, but shuttles be...

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Main Authors: Gallouzi, I E, Brennan, C M, Steitz, J A
格式: Artigo
語言:Inglês
出版: 2001
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1370177/
https://ncbi.nlm.nih.gov/pubmed/11565755
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