Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay.

The Upf1 protein in yeast has been implicated in the modulation of efficient translation termination as well as in the accelerated turnover of mRNAs containing premature stop codons, a phenomenon called nonsense-mediated mRNA decay (NMD). A human homolog of the yeast UPF1, termed HUpf1/RENT1, has al...

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Autores principales: Bhattacharya, A, Czaplinski, K, Trifillis, P, He, F, Jacobson, A, Peltz, S W
Formato: Artigo
Lenguaje:Inglês
Publicado: 2000
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1369996/
https://ncbi.nlm.nih.gov/pubmed/10999600
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