Maximizing RNA folding rates: a balancing act.

Large ribozymes typically require very long times to refold into their active conformation in vitro, because the RNA is easily trapped in metastable misfolded structures. Theoretical models show that the probability of misfolding is reduced when local and long-range interactions in the RNA are balan...

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Bibliografiske detaljer
Main Authors: Thirumalai, D, Woodson, S A
Format: Artigo
Sprog:Inglês
Udgivet: 2000
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1369958/
https://ncbi.nlm.nih.gov/pubmed/10864039
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