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Molecular interactions and metal binding in the theophylline-binding core of an RNA aptamer.

An RNA aptamer containing a 15-nt binding site shows high affinity and specificity for the bronchodilator theophylline. A variety of base modifications or 2' deoxyribose substitutions in binding-site residues were tested for theophyllinebinding affinity and the results were compared with the pr...

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Bibliografske podrobnosti
Main Authors: Zimmermann, G R, Wick, C L, Shields, T P, Jenison, R D, Pardi, A
Format: Artigo
Jezik:Inglês
Izdano: 2000
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1369946/
https://ncbi.nlm.nih.gov/pubmed/10836787
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