Sensitivity of splice sites to antisense oligonucleotides in vivo.

A series of HeLa cell lines which stably express beta-globin pre-mRNAs carrying point mutations at nt 654, 705, or 745 of intron 2 has been developed. The mutations generate aberrant 5' splice sites and activate a common 3' cryptic splice site upstream leading to aberrantly spliced beta-gl...

Full description

Saved in:
Bibliographic Details
Main Authors: Sierakowska, H, Sambade, M J, Schümperli, D, Kole, R
Format: Artigo
Language:Inglês
Published: 1999
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1369766/
https://ncbi.nlm.nih.gov/pubmed/10094306
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items