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The neurodegeneration mutant löchrig interferes with cholesterol homeostasis and Appl processing

The novel Drosophila mutant löchrig (loe) shows progressive neurodegeneration and neuronal cell death, in addition to a low level of cholesterol ester. loe affects a specific isoform of the γ-subunit of AMP-activated protein kinase (AMPK), a negative regulator of hydroxymethylglutaryl (HMG)-CoA redu...

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Detaylı Bibliyografya
Asıl Yazarlar: Tschäpe, Jakob-Andreas, Hammerschmied, Christine, Mühlig-Versen, Max, Athenstaedt, Karin, Daum, Günther, Kretzschmar, Doris
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2002
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC136940/
https://ncbi.nlm.nih.gov/pubmed/12456644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf636
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