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The neurodegeneration mutant löchrig interferes with cholesterol homeostasis and Appl processing
The novel Drosophila mutant löchrig (loe) shows progressive neurodegeneration and neuronal cell death, in addition to a low level of cholesterol ester. loe affects a specific isoform of the γ-subunit of AMP-activated protein kinase (AMPK), a negative regulator of hydroxymethylglutaryl (HMG)-CoA redu...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
2002
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC136940/ https://ncbi.nlm.nih.gov/pubmed/12456644 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf636 |
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