Loss of Swiss Cheese/Neuropathy Target Esterase Activity Causes Disruption of Phosphatidylcholine Homeostasis and Neuronal and Glial Death in Adult Drosophila

The Drosophila Swiss cheese (sws) mutant is characterized by progressive degeneration of the adult nervous system, glial hyperwrapping, and neuronal apoptosis. The Swiss cheese protein (SWS) shares 39% sequence identity with human neuropathy target esterase (NTE), and a brain-specific deletion of SW...

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Main Authors: Mühlig-Versen, Max, da Cruz, Alexandre Bettencourt, Tschäpe, Jakob-Andreas, Moser, Markus, Büttner, Reinhard, Athenstaedt, Karin, Glynn, Paul, Kretzschmar, Doris
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 2005
Assuntos:
Neurobiology of Disease
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1182176/
https://ncbi.nlm.nih.gov/pubmed/15772346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5097-04.2005
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