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Inverse transposition by the RAG1 and RAG2 proteins: role reversal of donor and target DNA

The lymphoid-specific proteins RAG1 and RAG2 initiate V(D)J recombination by introducing DNA double-strand breaks at the recombination signal sequences (RSSs). In addition to DNA cleavage, the versatile RAG1/2 complex is capable of catalyzing several other reactions, including hybrid joint formation...

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Udgivet i:EMBO J
Principais autores: Shih, I-hung, Melek, Meni, Jayaratne, Nadeesha D., Gellert, Martin
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2002
Fag:
Articles
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC136934/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12456668/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdf630
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