p53 modulates homologous recombination by transcriptional regulation of the RAD51 gene

DNA repair by homologous recombination is involved in maintaining genome stability. Previous data report that wild-type p53 suppresses homologous recombination and physically interacts with Rad51. Here, we show the in vivo binding of wild-type p53 to a p53 response element in the promoter of Rad51 a...

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Detaylı Bibliyografya
Asıl Yazarlar: Arias-Lopez, Carmen, Lazaro-Trueba, Iciar, Kerr, Peter, Lord, Christopher J, Dexter, Tim, Iravani, Marjan, Ashworth, Alan, Silva, Augusto
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2006
Konular:
Scientific Report
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1369244/
https://ncbi.nlm.nih.gov/pubmed/16322760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400587
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