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The hypoxia-inducible-factor hydroxylases bring fresh air into hypoxia signalling

Metazoans rapidly respond to changes in oxygen availability by regulating gene expression. The transcription factor hypoxia-inducible-factor (HIF), which controls the expression of several genes, ‘senses' the oxygen concentration indirectly through the hydroxylation of two proline residues that...

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Autors principals: Berra, Edurne, Ginouvès, Amandine, Pouysségur, Jacques
Format: Artigo
Idioma:Inglês
Publicat: 2006
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1369233/
https://ncbi.nlm.nih.gov/pubmed/16391536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400598
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