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Phosphorothioate-stimulated uptake of short interfering RNA by human cells
The cellular delivery of short interfering RNA (siRNA) is a main hurdle in therapeutic drug development. Here, we describe that phosphorothioate (PTO)-derived oligonucleotides stimulate the physical cellular uptake of siRNA in trans in human cells. This is reflected by an apparent dose-dependent siR...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1369202/ https://ncbi.nlm.nih.gov/pubmed/16170302 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400535 |
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