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Bcr–Abl activates the AKT/FoxO3 signalling pathway to restrict transforming growth factor-β-mediated cytostatic signals
The fusion of Abl with either Bcr or Tel in human leukaemia leads to the constitutive activation of Abl tyrosine kinase, which in turn induces growth-factor-independent proliferation and cell survival. However, the mechanism by which Bcr–Abl induces cellular transformation has not yet been well char...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1369182/ https://ncbi.nlm.nih.gov/pubmed/16113647 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400501 |
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