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Topoisomerase II–DNA complexes trapped by ICRF-193 perturb chromatin structure
DNA topoisomerase II (topo II) is involved in unlinking replicating DNA and organizing mitotic chromosomes. Topo II is the target of many antitumour drugs. Topo II inhibition results in extensive catenation of newly replicated DNA and may potentially perturb chromatin assembly. Here, we show that th...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2005
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1369141/ https://ncbi.nlm.nih.gov/pubmed/16025133 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400465 |
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