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Casein kinase II–dependent phosphorylation of DNA topoisomerase II suppresses the effect of a catalytic topo II inhibitor, ICRF-193, in fission yeast

DNA topoisomerase II (topo II) regulates the topological state of DNA and is necessary for DNA replication, transcription, and chromosome segregation. Topo II has essential functions in cell proliferation and therefore is a critical target of anticancer drugs. In this study, using Phos-tag SDS-PAGE...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Nakazawa, Norihiko, Arakawa, Orie, Ebe, Masahiro, Yanagida, Mitsuhiro
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6416453/
https://ncbi.nlm.nih.gov/pubmed/30635402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004955
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