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DNA topoisomerase IIα controls replication origin cluster licensing and firing time in Xenopus egg extracts
Sperm chromatin incubated in Xenopus egg extracts undergoes origin licensing and nuclear assembly before DNA replication. We found that depletion of DNA topoisomerase IIα (topo IIα), the sole topo II isozyme of eggs and its inhibition by ICRF-193, which clamps topo IIα around DNA have opposite effec...
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| Asıl Yazarlar: | , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Oxford University Press
2013
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3753627/ https://ncbi.nlm.nih.gov/pubmed/23757188 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt494 |
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