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DNA topoisomerase IIα controls replication origin cluster licensing and firing time in Xenopus egg extracts

Sperm chromatin incubated in Xenopus egg extracts undergoes origin licensing and nuclear assembly before DNA replication. We found that depletion of DNA topoisomerase IIα (topo IIα), the sole topo II isozyme of eggs and its inhibition by ICRF-193, which clamps topo IIα around DNA have opposite effec...

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Bibliografski detalji
Glavni autori: Gaggioli, Vincent, Le Viet, Barbara, Germe, Thomas, Hyrien, Olivier
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3753627/
https://ncbi.nlm.nih.gov/pubmed/23757188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt494
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